Description
AICAr (5-Aminoimidazole-4-carboxamide ribonucleotide) is a potent activator of AMP-activated protein kinase (AMPK) used in a variety of metabolic and cellular studies. As a precursor in purine biosynthesis, it is widely utilized in in vitro research for exploring mechanisms of cellular energy regulation and metabolic signaling pathways. Its chemical properties and stability make it ideal for controlled laboratory experiments focused on metabolic diseases, exercise mimetics, and energy balance studies.
Developed using advanced synthetic techniques, AICAr has been engineered for high solubility and precision in experimental settings. This ensures its compatibility with a range of research applications, from investigating energy-dependent pathways to assessing cellular responses under various stress conditions. Its ability to stimulate AMPK activation has positioned AICAr as a critical compound for studying metabolic syndromes and related cellular responses.
The synthesis and refinement processes for AICAr follow stringent Acceptable Quality Level (AQL) standards, producing a compound that is both reliable and reproducible for laboratory use. Its lyophilized form ensures extended shelf life and ease of reconstitution for detailed biochemical analysis.
This product is classified as Research Use Only (RUO). Labs who are ordering reconstitution should refer to our terms and conditions for specific usage guidelines.
| Property | Detail |
| Chemical | AICAr |
| Synonyms | Acadesine, 5-Aminoimidazole-4-carboxamide ribonucleotide |
| Sequence | |
| Molecular Weight | 258.22 g/mol |
| Formula | C9H14N4O5 |
| CAS Number | 2627-69-2 |
| Solid Solubility | Soluble in sterile water |
| Storage | Store at -20°C |
| PubChem CID | 135398648 |


Certificate of Analysis
Lone Star Research ensures the highest quality of AICAr through rigorous analytical testing. The Certificate of Analysis (COA) verifies the compound’s integrity and reliability for research purposes.
| Parameter | Detail | Result |
| Lot number | LSRAICAR2024-094 | ☑ VALID |
| MFG Date | 10/15/2024 | ☑ VALID |
| Expiration Date | 12/31/2027 | ☑ VALID |
| Appearance | Lyophilized powder | ☑ PASS |
| Solubility | Clear in sterile water | ☑ PASS |
| HPLC | Purity ≥98% | ☑ 99.2% |
| Amino Acid Analysis | Tyr, D-Ala, Asp, Ala, Ile, Phe | ☑ PASS |
| Mass Spectrum | 258.22 g/mol | ☑ 258.20 g/mol |
Storage Protocols
Proper storage is critical to maintaining the stability and efficacy of AICAr. Exposure to suboptimal conditions can lead to degradation and reduced performance in research applications. Consistent storage conditions are recommended to preserve product integrity.
| Storage Condition | Duration |
| Frozen (-20°C) | Up to 3 years |
| Refrigerated (4°C) | Up to 3 months |
| After Reconstitution | Use within 28 days at 4°C |
- Store in a tightly sealed container to avoid contamination.
- Protect from light to maintain chemical stability.
- Avoid repeated freeze-thaw cycles to prevent degradation.

Lone Star Research Storage Protocols:
Lone Star Research employs advanced storage solutions, including medical-grade freezers and refrigeration systems. Backup generators and continuous temperature monitoring ensure product stability at all times. Temperature logs are recorded to the cloud and audited quarterly to maintain high standards.
Lonestar Reconstitution Protocols:
AICAr is reconstituted under stringent conditions, following sterility guidelines in controlled environments with negative pressure. Reconstituted chemicals are non-returnable due to their sensitive handling requirements.


Lyophilized Powder (Standard)
A freeze-dried, stable form of the chemical, ideal for long-term storage. Typically stable for up to 2 years when stored properly. Keep frozen at -20°C to maintain stability.
Reconstituted (Ready-to-Use) A pre-prepared, liquid form reconstituted with up to 2.5 mL of bacteriostatic water for convenience. Use within 28 days when stored at 4°C after reconstitution.
Signs of Degradation (After Reconstitution):
- Formation of particulates or cloudiness.
- Loss of clarity or discoloration.
- Reduced bioactivity in research applications.
Proper handling and storage are essential to maintain the efficacy of most peptides. Lone Star Research is not responsible for mishandling or temperature fluctuations after the product leaves our facility. Please see our Return policy for more details.

Free FedEx 2 Day Shipping
All research chemicals are shipped free of charge via FedEx 2nd Day Air, using thermally regulated packaging with cold packs to maintain stability during transit. If reconstitution is requested, adherence to temperature requirements is critical to preserve chemical potency. Improper handling may compromise the compound’s efficacy. We only ship Monday – Wednesday to ensure chemicals arrive to your lab in good condition.
| Order by 11pm Monday | Ships Tuesday |
| Order by 11pm Tuesday | Ships Wednesday |
| Order anytime Wednesday – Sunday | Ships following Monday |









