Description
TB-500, the synthetic variant of the naturally occurring Thymosin Beta-4 peptide, has been meticulously engineered for in vitro research applications. It has garnered significant interest for its role in cellular migration, angiogenesis, and actin regulation. TB500 allows labs to explore cellular behavior and regeneration processes in controlled environments.
Developed using advanced peptide synthesis, TB-500 exhibits enhanced stability and reliability under research conditions. Its structural similarity to Thymosin Beta-4 ensures consistent interactions with actin-binding sites, facilitating studies on cellular cytoskeleton dynamics. This peptide is especially valuable in research involving tissue repair and cell proliferation mechanisms.
TB-500 is supplied as a lyophilized powder for optimal storage and ease of reconstitution. Rigorous quality assurance ensures that this compound meets or exceeds acceptable quality levels for laboratory-grade peptides. Labs who are ordering this product are advised to carefully adhere to handling and storage instructions to preserve its integrity.
This product is categorized as Research Use Only (RUO). Labs should review our terms and conditions for additional compliance information.
| Property | Detail |
| Chemical | TB-500 |
| Synonyms | Thymosin Beta-4 Acetate, TB4 Analog |
| Sequence | Ac-LKKTETQEKNTVQEKQAGES |
| Molecular Weight | 4963.44 g/mol |
| Formula | C212H350N56O78S |
| CAS Number | 77591-33-4 |
| Solid Solubility | Soluble in sterile water |
| Storage | Store at -20°C |
| PubChem CID | 3081385 |


Certificate of Analysis
Lone Star Research ensures the highest quality of TB-500 through rigorous analytical testing. The Certificate of Analysis (COA) verifies the compound’s integrity and reliability for research purposes.
| Parameter | Detail | Result |
| Lot number | LSR-TB500-112024 | ☑ VALID |
| MFG Date | 11/15/2024 | ☑ VALID |
| Expiration Date | 11/30/2027 | ☑ VALID |
| Appearance | Lyophilized powder | ☑ PASS |
| Solubility | Clear in sterile water | ☑ PASS |
| HPLC | Purity ≥98% | ☑ 98.7% |
| Amino Acid Analysis | Tyr, D-Ala, Asp, Ala, Ile, Phe | ☑ PASS |
| Mass Spectrum | 4963.44 g/mol | ☑ 4963.41 g/mol |
Storage Protocols
Proper storage is critical to maintaining the stability and efficacy of TB-500. Exposure to suboptimal conditions can lead to degradation and reduced performance in research applications. Consistent storage conditions are recommended to preserve product integrity.
| Storage Condition | Duration |
| Frozen (-20°C) | Up to 3 years |
| Refrigerated (4°C) | Up to 3 months |
| After Reconstitution | Use within 28 days at 4°C |
- Store in a tightly sealed container to avoid contamination.
- Protect from light to maintain chemical stability.
- Avoid repeated freeze-thaw cycles to prevent degradation.

Lone Star Research Storage Protocols:
Lone Star Research employs advanced storage solutions, including medical-grade freezers and refrigeration systems. Backup generators and continuous temperature monitoring ensure product stability at all times. Temperature logs are recorded to the cloud and audited quarterly to maintain high standards.
Lonestar Reconstitution Protocols:
TB-500 is reconstituted under stringent conditions, following sterility guidelines in controlled environments with negative pressure. Reconstituted chemicals are non-returnable due to their sensitive handling requirements.


Lyophilized Powder (Standard)
A freeze-dried, stable form of the chemical, ideal for long-term storage. Typically stable for up to 2 years when stored properly. Keep frozen at -20°C to maintain stability.
Reconstituted (Ready-to-Use) A pre-prepared, liquid form reconstituted with up to 2.5 mL of bacteriostatic water for convenience. Use within 28 days when stored at 4°C after reconstitution.
Signs of Degradation (After Reconstitution):
- Formation of particulates or cloudiness.
- Loss of clarity or discoloration.
- Reduced bioactivity in research applications.
Proper handling and storage are essential to maintain the efficacy of most peptides. Lone Star Research is not responsible for mishandling or temperature fluctuations after the product leaves our facility. Please see our Return policy for more details.

Free FedEx 2 Day Shipping
All research chemicals are shipped free of charge via FedEx 2nd Day Air, using thermally regulated packaging with cold packs to maintain stability during transit. If reconstitution is requested, adherence to temperature requirements is critical to preserve chemical potency. Improper handling may compromise the compound’s efficacy. We only ship Monday – Wednesday to ensure chemicals arrive to your lab in good condition.
| Order by 11pm Monday | Ships Tuesday |
| Order by 11pm Tuesday | Ships Wednesday |
| Order anytime Wednesday – Sunday | Ships following Monday |









